Timeline of Antibiotics

The timeline shows the dates when antibiotics were put on the market. It does not show their pharmaceutical and clinical development.

1911 – Arsphenamine a.k.a. Salvarsan

1912 – Neosalvarsan

1935 – Prontosil (an oral precursor to sulfanilamide), the first sulfonamide

1936 – Sulfanilamide

1938 – Sulfapyridine (M&B 693)

1939 – sulfacetamide

1940 – sulfamethizole

1942 – benzylpenicillin, the first penicillin

1942 – gramicidin S, the first peptide antibiotic

1942 – sulfadimidine

1943 – sulfamerazine

1944 – streptomycin, the first aminoglycoside

1947 – sulfadiazine

1948 – chlortetracycline, the first tetracycline

1949 – chloramphenicol, the first amphenicol

1949 – neomycin

1950 – oxytetracycline

1950 – penicillin G procaine

1952 – erythromycin, the first macrolide

1954 – benzathine penicillin

1955 – spiramycin

1955 – tetracycline

1955 – thiamphenicol

1955 – vancomycin, the first glycopeptide

1956 – phenoxymethylpenicillin

1958 – colistin, the first polymyxin

1958 – demeclocycline

1959 – virginiamycin

1960 – methicillin

1960 – metronidazole, the first nitroimidazole

1961 – ampicillin

1961 – spectinomycin

1961 – sulfamethoxazole

1961 – trimethoprim, the first dihydrofolate reductase inhibitor

1962 – cloxacillin

1962 – fusidic acid

1963 – fusafungine

1963 – lymecycline

1964 – gentamicin

1964 – cefalotin, the first cephalosporin

1966 – doxycycline

1967 – carbenicillin

1967 – rifampicin

1967 – nalidixic acid, the first quinolone

1968 – clindamycin, the second lincosamide

1970 – cefalexin

1971 – cefazolin

1971 – pivampicillin

1971 – tinidazole

1972 – amoxicillin

1972 – cefradine

1972 – minocycline

1972 – pristinamycin

1973 – fosfomycin

1974 – talampicillin

1975 – tobramycin

1975 – bacampicillin

1975 – ticarcillin

1976 – amikacin

1977 – azlocillin

1977 – cefadroxil

1977 – cefamandole

1977 – cefoxitin

1977 – cefuroxime

1977 – mezlocillin

1977 – pivmecillinam

1979 – cefaclor

1980 – cefmetazole

1980 – cefotaxime

1980 – piperacillin

1981 – co-amoxiclav (amoxicillin/clavulanic acid)

1981 – cefoperazone

1981 – cefotiam

1981 – cefsulodin

1981 – latamoxef

1981 – netilmicin

1982 – ceftriaxone

1982 – micronomicin

1983 – cefmenoxime

1983 – ceftazidime

1983 – ceftizoxime

1983 – norfloxacin

1984 – cefonicid

1984 – cefotetan

1984 – temocillin

1985 – cefpiramide

1985 – imipenem/cilastatin, the first carbapenem

1985 – ofloxacin

1986 – mupirocin

1986 – aztreonam

1986 – cefoperazone/sulbactam

1986 – co-ticarclav (ticarcillin/clavulanic acid)

1987 – ampicillin/sulbactam

1987 – cefixime

1987 – roxithromycin

1987 – sultamicillin

1987 – ciprofloxacin, the first 2nd-gen fluoroquinolone

1987 – rifaximin, the first ansamycin

1988 – azithromycin

1988 – flomoxef

1988 – isepamycin

1988 – midecamycin

1988 – rifapentine

1988 – teicoplanin

1989 – cefpodoxime

1989 – enrofloxacin

1989 – lomefloxacin

1989 – moxifloxacin

1990 – arbekacin

1990 – cefodizime

1990 – clarithromycin

1991 – cefdinir

1992 – cefetamet

1992 – cefpirome

1992 – cefprozil

1992 – ceftibuten

1992 – fleroxacin

1992 – loracarbef

1992 – piperacillin/tazobactam

1992 – rufloxacin

1993 – brodimoprim

1993 – dirithromycin

1993 – levofloxacin

1993 – nadifloxacin

1993 – panipenem/betamipron

1993 – sparfloxacin

1994 – cefepime

1996 – meropenem

1999 – quinupristin/dalfopristin

2000 – linezolid, the first oxazolidinone

2001 – telithromycin, the first ketolide

2003 – daptomycin

2005 – tigecycline, the first glycylcycline

2005 – doripenem

2009 – telavancin, the first Lipoglycopeptide

2010 – ceftaroline

2011 – fidaxomicin

2012 – bedaquiline

2013 – telavancin

2014 – tedizolid

2014 – dalbavancin

2014 – ceftolozane/tazobactam

2015 – ceftazidime/avibactam

Source https://en.wikipedia.org/wiki/Timeline_of_antibiotics
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